Bisoprolol and metoprolol are not recommended to be used together, because these two medicines belong to the same category of beta-blockers, but the side effects and contraindications are different, and need to be adjusted under the guidance of the doctor. 1. Bisoprolol: Bisoprolol fumarate acts on beta receptors and can be used to treat high blood pressure and coronary heart disease, among others. After taking the drug, adverse reactions may occur, such as weakness, indigestion, dizziness, bronchospasm, insomnia and other symptoms. It is forbidden to use it for people with allergy, cardiogenic shock, bradycardia and low blood pressure. 2. Metoprolol: Metoprolol tartrate tablets belong to selective beta receptor antagonist drugs, which can be clinically used in the treatment of hypertension, angina pectoris and other diseases. After taking the drug, symptoms such as shortness of breath, diarrhea, stool fatigue, sleep disorders and dizziness may occur. It is prohibited for people with allergies, conduction block, bradycardia, severe or acute heart failure. When taking the drug, it should be taken under the guidance of a doctor, do not take the drug without authorization to avoid serious consequences.