If acute or severe pain occurs in the stomach at night, it needs to be considered to be caused by the following diseases: 1, duodenal ulcer, patients suffering from this kind of disease, usually after meals or at night, it is easy to appear in the stomach and epigastric department of severe pain and heartburn and other symptoms, but the pain will be gradually relieved after taking food, this is due to the damage of gastric acid on the ulcer. Need to improve the gastroscopy, while using drugs to protect the gastric mucosa for treatment. 2, appendicitis, if the acute pain at night, and the site of pain in the right lower abdomen, and also accompanied by abdominal wall tension and other symptoms, we need to consider the appendicitis. Appendicitis can lead to concurrent peritonitis, which can lead to abdominal muscle tension and rebound pain, etc. 3, pancreatitis, acute pancreatitis can also lead to severe stomach pain, but the pain is usually in the left upper abdomen, and most of the time at dinner, there is overeating behavior.