Numbness in the thumb can be seen in central causes as well as peripheral causes. The common causes are as follows: 1, central causes, lacunar cerebral infarction, damage to the conduction pathways of the thalamic tract of the spinal cord projecting to the cortex, such as the basal ganglia, the thalamus, the semi-oval center, and the postcentral gyrus sensory area. It can be treated with drugs that improve central blood circulation, such as Schisandra points, and oral drugs that nourish the nerves.2. Cervical spondylosis, cervical disc herniation compressing nerves, such as cervical 5-6 disc herniation.3. Peripheral neuritis, such as peripheral neuropathy caused by diabetes.4. Pharmacological factors, such as patients with tuberculosis, oral isoniazid causing nerve damage.5. Peripheral neuropathy caused by chemical factors.6. To identify central thumb tingling, or peripheral causes, nerve conduction velocity examination of the upper extremity can be done, as well as imaging of the head, and the application of nerve-nourishing drugs is required for the treatment of either cause.