Quadruple therapy refers to the quadruple eradication of H. pylori therapy, which includes acid-suppressing drugs, bismuth preparations and two antibiotics, most people eat quadruple drugs are very safe, there are not much adverse reactions, some people may have more stools and more volume, which may still be related to the quadruple drugs have some side effects. At the same time, there may be some interference with the diet during the medication, it is recommended that during the sterilization period is best to control the diet, avoid eating cold, cold, stimulating diet may lead to an increase in the number of stools. In addition, quadruple therapy is recommended to take two weeks of antibiotics, some people may lead to an imbalance of intestinal flora, which will lead to an increase in the number of stools, but these conditions will gradually get better as soon as the drug is stopped. Therefore, during the course of taking the medication, patients are advised not to eat spicy and stimulating foods to avoid aggravating the adverse effects of the medication.