Shoulder pain may be caused by physiological factors such as overexertion, or pathological factors such as cervical spondylosis, frozen shoulder, rotator cuff injury, etc. Oral non-steroidal, nutritive nerve and muscle relaxation drugs can be chosen according to the cause. 1. Physiological factors: Excessive exercise often leads to excessive fatigue of the tissues around the shoulder joint and accumulation of lactic acid, causing pain in the shoulder joint, which does not require special treatment and can be gradually relieved after proper rest. 2. Cervical spondylosis: Shoulder pain caused by cervical spondylosis compression of nerves can be accompanied by pain and numbness of one or both upper limbs. Under the guidance of a doctor, you can take oral nutritive nerve medications such as methylcobalamin dispersible tablets, oral non-steroidal painkillers such as nimesulide, ibuprofen, etc., and you can also take oral nutritive nerve medications such as methylcobalamin. 3. Frozen shoulder: Frozen shoulder can cause pain in the shoulder joint, accompanied by limited movement of the joint, you can take oral non-steroidal painkillers, you can also take oral muscle relaxants such as Epirubicin, Chlorzoxazone and so on. 4. Rotator cuff injury: due to trauma or improper exercise can cause rotator cuff injury, which can cause shoulder pain, you can take non-steroidal painkillers, such as diclofenac sodium enteric-coated tablets, celecoxib and so on. Shoulder pain need to go to the hospital to find out the cause of the cause to take targeted treatment, the use of medication to follow the doctor’s instructions, to avoid their own blind use of drugs, so as not to delay the condition.