Gastroesophageal reflux disease is an upper gastrointestinal tract motility disorder, a disease in which the contents of the stomach and duodenum reflux into the esophagus causing clinical symptoms and inflammation of the esophagus. Currently, most patients with GERD are young and middle-aged people, because this disease is directly related to poor lifestyle, such as long-term mental tension and much sitting and less movement, smoking and alcohol abuse. These bad habits can easily cause neuroregulatory dysfunction of the digestive system, which relaxes the sphincter at the junction of the esophagus and stomach, resulting in failure to close properly after eating and causing reflux. Patients often experience a series of symptoms such as acid reflux, heartburn and vomiting. In addition, some patients are often misdiagnosed as pharyngitis and chronic cough because of foreign body sensation in the throat, cough and asthma. The accelerated pace of work, irregular diet, and excessive mental stress can all be factors that trigger the disease. Therefore, young people have become the key target of GERD attack. GERD can be treated with lifestyle changes, medications, and surgical procedures. Lifestyle changes such as elevating the head of the bed, not eating 3 hours before bedtime, avoiding high-fat foods, quitting smoking and alcohol, and losing weight can benefit some GERD patients, but these changes are not sufficient to control symptoms for most patients. Therefore, acid suppression therapy is currently the basic treatment for GERD. Drugs that inhibit gastric acid include H2 receptor antagonists and proton pump inhibitors.