Most drugs must be taken with warm water, but you cannot take medicine with Coke. Coke is a carbonated beverage, and the carbonic acid may react with some drug ingredients and cause some calcium carbonate crystals or other adverse reactions, so you should not take medicine at the same time when drinking Coke. Most of the drugs are taken with warm water, sublingual or chewed, and some dispersible tablets are dissolved in water and then drunk. Very few drugs are fat-soluble and may require milk and other liquids to be taken, but no drugs can be taken with cola. Therefore, you must not take medicine with cola, and cola is a carbonated drink that can damage the mucous membrane of the gastrointestinal tract.