Cramps in the middle of the night have different causes and different ways to relieve them, which can be relieved by keeping warm, calcium supplementation and anti-epileptic drug treatment. 1. Cold: If the legs are cold for a long time at night, it can cause local muscle spasm and contraction, causing cramp symptoms. 2. Calcium deficiency: If long-term poor dietary habits, excessive partiality, picky eating, resulting in a lack of nutrients, especially when the lack of calcium, resulting in low blood calcium levels, easy to cause muscle spasms, can be in the middle of the night cramps symptoms, can be relieved by calcium supplementation, such as oral calcium gluconate, calcium tablets and other methods to alleviate the symptoms. 3. Epilepsy: sudden cramps in the middle of the night may also be caused by epilepsy, and can be treated with antiepileptic drugs such as sodium valproate and carbamazepine to relieve symptoms. The symptoms of cramps in the middle of the night, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease, and then targeted treatment.