When you have many small blisters on your mouth, you need to carefully observe the appearance of the small blisters. If the blisters are unilaterally distributed around the lips, densely arranged and can be accompanied by pain, it is considered herpes simplex disease caused by infection with herpes simplex type 1 virus, related to anxiety, fire and staying up late, it is recommended to take oral vaxilovir hydrochloride and use topical glyburide lotion for comprehensive treatment. After the blisters have dried up, change to topical application of recombinant human interferon gel, which can quickly make the small blisters subside. If the small blisters on the mouth are scattered and hard to the touch with your hands on the outer wall, consider it to be glandular labyrinthitis simplex and suggest topical application of tacrolimus ointment. If there is yellow or white pus inside the blisters, it is considered to be perioral impetigo and it is recommended to take oral minocycline or cephalosporins and apply topical fusidic acid cream.