There is no definitive time for reapplication of fusidic acid cream after discontinuation; 1-2 weeks is generally recommended. Fusidic acid cream is indicated for a variety of bacterial skin infections, mainly for skin infections caused by gram-positive cocci. For example, impetigo, boils, folliculitis, onychomycosis, sweatshirt, erysipelas, acne vulgaris, trauma co-infections, eczema co-infections, and ulcer co-infections. Fusidic acid cream is applied topically to the affected areas of the skin, avoiding irritation of the eyes and other mucous membranes. The metabolism of fusidic acid cream is mainly through the biliary excretion of the hepatobiliary system, and a small amount through the urinary excretion. If used repeatedly over a long period of time, it may increase the risk of bacterial resistance, and there is also an increased risk of contact allergy. Therefore, topical application of fusidic acid cream is not recommended for more than two weeks. There is no definite time for reapplication after discontinuation; 1-2 weeks is generally recommended. The exact method of administration should be followed and self-medication should be avoided.