Different people have different pain sensitivities, which may be related to genetic inheritance or educational and cognitive experience. Some studies have found that patients undergoing laparoscopic appendectomy differ significantly in their pain tolerance and response to the effects of pain medication due to differences in ethnicity, religious beliefs, educational background and health knowledge. Therefore, before the surgery, if you know more about the disease you are suffering from, the surgical procedure and pain relief, it will help you to reduce anxiety and fear during the surgery and alleviate the pain sensation. If you are pain sensitive, there are still many ways for your doctor to control pain. Choosing multiple methods of pain relief to achieve optimal pain relief is called multimodal pain relief. Before the end of the surgery, your doctor will inject long-acting pain medication around the incision, which will keep you from feeling excessive pain from the incision for 1 to 2 days after you wake up from anesthesia, and will help you sleep normally. Regularly timed intravenous input of pain medication at regular intervals after surgery allows patients to control their pain well before they feel severe pain. The use of localized medications in combination with systemic medications can further reduce pain and discomfort caused by early activity and irritation such as drains. The pain pump’s self-administered method of drug delivery allows you to adjust the dose of medication to relieve the pain yourself, depending on the severity of the pain you perceive. If the effect is very persistent, we will call upon “morphine”, the “ultimate pain killer”, to solve the problem. There are also new techniques such as transdermal infusion of pain medication that can make patients feel more and more comfortable with pain during surgery.