Recurrent mouth ulcers will heal on their own after removing the irritating factors, while other diseases such as leukemia and radiation stomatitis cause difficulty in self-healing. 1. can be self-healing: recurrent oral ulcers etiology is unknown, may be related to immune, genetic, environmental factors, but has the ability of cyclical and self-healing, but also can be used to accelerate the healing of the ulcer of the drug cediriodine tablets, prednisone and other drugs. 2. Difficult to self-healing: when suffering from leukemia, there will be ulcers in many parts of the mouth, eyes and genitals, and there is no effective cure, but only local use of colchicine for control. Accepting radiation exposure will cause radiation stomatitis, not to control the dose of irradiation or protection ulcers are difficult to heal, clinical treatment using epidermal growth factor drugs to reduce symptoms and promote healing. Ulcers caused by triggers are difficult to heal on their own, it is recommended to consult a doctor in a timely manner and follow the doctor’s instructions for medication.