Immunohistochemistry P16+ and Ki67+ are immunohistochemistry test results done primarily for the cervix. Immunohistochemistry P16+ and Ki67+ are immunohistochemical tests performed on a cervical biopsy to differentiate between low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions. Immunohistochemistry P16+ and Ki67+ are usually indicative of partial squamous intraepithelial neoplasia of the cervix with a low grade. In addition, if both P16 and Ki67 positivity exceeds 2/3 of the squamous epithelial layers, it is a high-grade lesion, if P16 and Ki67 positivity does not exceed 1/3 of the layers, it is a low-grade lesion, and if they are both base-positive, it is normal. Therefore, it is recommended to combine the results of the test, combined with cooperation with the doctor for treatment, to avoid delayed treatment leading to serious conditions.