Helicobacter pylori generally does not directly cause elevated alpha-fetoprotein, elevated alpha-fetoprotein in pregnant women with Helicobacter pylori is generally caused by pregnancy; Helicobacter pylori infection may cause gastric cancer, and patients with gastric cancer will have elevated alpha-fetoprotein; it may also be caused by hepatocellular carcinoma, etc., which causes elevated alpha-fetoprotein and Helicobacter pylori infection at the same time. 1. Physiological reasons: fetus can synthesize alpha-fetoprotein, if pregnant women are infected with Helicobacter pylori, the elevated alpha-fetoprotein may be caused by pregnancy, which is a normal physiological phenomenon. 2. Pathological reasons: Helicobacter pylori infection may cause gastric cancer, gastric cancer and other malignant tumors may appear elevated alpha-fetoprotein, you can do gastroscopy and other clear diagnosis. Elevated alpha-fetoprotein may also be caused by liver cancer, liver cirrhosis, hepatitis, etc., accompanied by H. pylori infection, which can be detected by tumor marker test, liver function test and hepatitis virus test. If H. pylori infection is accompanied by elevated alpha-fetoprotein and physiological reasons such as pregnancy are excluded, the patient should consult a doctor for a detailed examination and a clear diagnosis under the guidance of the doctor.