Hypertension is a clinical syndrome characterized by increased blood pressure in the arteries of the body circulation, which may be accompanied by functional or organic damage to the heart, brain, kidneys and other organs. According to the latest guidelines, there are six major classes of antihypertensive drugs available clinically.1. Calcium antagonists: mainly by inhibiting the inward flow of calcium ions in blood vessels or cardiomyocytes, thus making the calcium-mediated excitation-contraction coupling of cardiac muscle or smooth muscle is weakened, allowing vasodilation, thus playing a role in lowering blood pressure. The main clinical drugs are diphenhydramine, including nifedipine, amlodipine and felodipine, etc.; 2, angiotensin-converting enzyme inhibitors (ACEI): mainly inhibit the activation of the ROS system, thus playing the role of inhibiting neuroendocrine hyperactivation, playing the effect of vasodilation, urination and so on. Representative drugs include captopril, perindopril, benazepril, fosinopril, etc.; 3, angiotensin receptor antagonists: similar mechanism of action to ACEI drugs, with fewer clinical side effects than ACEI drugs and clearer antihypertensive effect, the main representative drugs are sartans, including valsartan, cloxacin, irbesartan, olmesartan, etc.; 4, beta-blockers: by reducing myocardial The main representative drugs are metoprolol tartrate or bisoprolol fumarate, etc.; 5, diuretics: through reducing water and sodium retention, reducing the heart and the body’s volume load to play a role in lowering blood pressure, the main drugs are hydrochlorothiazide, furosemide, etc.; 6, angiotensin receptor enkephalinase inhibitors (ARNI): the representative drugs are Shakubatril Valsartan sodium, is a new comprehensive antihypertensive drug, the effect of lowering blood pressure is exact, while the protection of target organs such as heart, brain and kidney is more clear.