Myeloma cells, also known as malignant plasma cells, plasma cells accounted for 38.5% generally refers to the proportion of bone marrow monoclonal plasma cells is 38.5%, most often considered as multiple myeloma, belong to the malignant disease, more serious. Multiple myeloma is a kind of malignant tumor disease with abnormal proliferation of clonal plasma cells as the main manifestation, mostly occurring in the elderly, currently incurable. Multiple myeloma is divided into asymptomatic (smoldering) myeloma and symptomatic (active) myeloma. 1. Diagnosis of asymptomatic myeloma: the proportion of monoclonal plasma cells in bone marrow is 10%~59% + no damage to related organs and tissues. 2. Diagnosis of symptomatic myeloma: bone marrow monoclonal plasma cell percentage ≥10% + serum and/or urine monoclonal M protein + myeloma-related manifestations. In recent years, new drugs (bortezomib, thalidomide) and the widespread use of hematopoietic stem cell transplantation have led to a significant increase in the overall survival rate of multiple myeloma, but at present, multiple myeloma is still incurable, and will eventually relapse or progress. Standardized treatment can help patients achieve a deeper degree of remission and a longer survival time. Myeloma cells account for 38.5% of all cases, and timely selection of appropriate treatment under the guidance of a specialist is recommended.