Calluses on the soles of the feet may be corns, calluses, plantar warts and other diseases. It may be localized by friction, ill-fitting shoes, foot deformities, viral infections and other factors. 1. corns: corns can occur in the foot, and long-term extrusion, friction, wearing shoes that do not fit, foot deformity related. The friction part can appear yellowish or dark yellow limited keratinous growths, which may be accompanied by pain when the force is exerted. 2. Callus: local long-term mechanical stimulation, friction, pressure, is the main cause of callus. Repeated mechanical stimulation, friction, may lead to hyperkeratosis of the skin, localized hard yellow plaques may appear, accompanied by pressure pain. 3. metatarsal warts: metatarsal warts are caused by human papilloma virus infection of the skin of the foot, the virus infection invades the local skin, resulting in localized yellowish rough patches of skin, after removing the surface keratin can be seen as a needle tip size black spots, accompanied by pain when pressed. Regardless of the cause of calluses on the soles of the feet, it is recommended that the patient to reduce the adverse stimulation, friction, extrusion, and timely access to the regular hospital dermatology department, a clear diagnosis of standardized treatment in accordance with the doctor’s instructions. If accompanied by foot deformity, surgery can be considered if necessary.