Many diseases in pediatrics are caused by viruses, and patients with viral infections can easily cause nosocomial infections if they are not handled properly, especially in pediatric patients. Common antiviral drugs include oseltamivir, paramivir and zanamivir for influenza, acyclovir and ganciclovir for viral pneumonia and encephalitis, and some proprietary Chinese medicines for hand, foot and mouth disease. At present, there is no special anti-intestinal viral drugs, if the application of interferon, ribavirin has a certain effect, but should pay attention to the adverse effects of ribavirin and reproductive toxicity. If you use Chinese medicine, you should treat with the principle of clearing heat and removing dampness and detoxification, such as Pu Di Lan, Healing New Solution, Six Gods Pill and so on. For children, the most important thing is to pay attention to the adverse reactions, one is for the children’s own physiological characteristics, and the second is that most of the drugs used in children have not been clinically studied, so many of the instructions are missing the basis for children’s medication. In addition, the adverse reactions of antiviral drugs are mainly gastrointestinal reactions with nausea, vomiting, abdominal distension and diarrhea, and allergic reactions with fever and skin rash. Besides, some drugs can cause elevated transaminases. Before using antiviral drugs, it should be determined whether it is caused by a viral infection or by which virus. If it is not determined which virus is causing the disease, broad-spectrum antiviral drugs can be used. After the diagnosis is clear, the route of administration is determined symptomatically according to the site of infection, and the dose and course of medication are determined according to the severity.