Patients with herpes simplex virus type 1 infection of the skin cause most of the fire and blistering in the human middle, manifested as erythema in the human middle area of the upper lip, with pinpoint blisters that can be touched on the erythema, which can have symptoms of burning, pain and discomfort, the cause of blistering is mainly infection with the herpes simplex virus, which is related to the patient’s low immune function for a period of time. The patient has a cold, fever, anxiety, fire, staying up late, overwork, etc., can trigger the disease, after the blisters, treatment can be oral antiviral drugs, such as famciclovir or valacyclovir hydrochloride, can quickly relieve the condition, local can also use 3% boric acid solution wet compress, with swelling, anti-inflammatory effect, can also be combined with the topical application of penciclovir cream.