Muscles always jumping on their own may be caused by physiological factors, such as mental stress, excessive fatigue, etc.; it may also be caused by pathological factors, such as the following motor neuron disease, anxiety disorders. 1. Physiological factors: patients may suffer from mental stress, excessive fatigue, nervousness, insomnia, or drinking strong tea, coffee and other excitatory beverages, which may lead to the situation that the muscles are always jumping on their own. 2. Pathological factors (1) Lower motor neuron disease: due to the accumulation of toxic substances in the nervous system, and damage to nerve cells, resulting in muscle atrophy, decreased muscle tone, visible muscle twitching, resulting in the patient’s muscles always jumping by themselves. (2) Anxiety disorders: for patients with chronic anxiety, motor restlessness occurs, which is manifested as fidgeting, rubbing hands and feet, tense muscle pain and tremor of tongue, lips and finger muscles. Make the patient appear the symptoms of muscles always jumping by themselves. Muscles always jumping by themselves may have other reasons, it is recommended that patients seek medical attention in a timely manner to clarify the cause of the disease, follow the doctor’s instructions for standardized treatment.