Food does not have a therapeutic effect on low fibrinogen, and clinical treatment for low fibrinogen mainly includes medication and supportive therapy. Fibrinogen is a protein synthesized by liver cells for blood clotting, so some diseases that cause liver function abnormality such as severe hepatitis B and cirrhosis can lead to a decrease in fibrinogen synthesized by liver cells. For low fibrinogen caused by severe hepatitis B, the main treatment measures include antiviral drugs such as entecavir, supportive treatment such as bed rest and maintenance of water-electrolyte balance, and liver-protective treatment such as reduced glutathione and bicyclic alcohol. For low fibrin caused by cirrhosis, treatment measures include active treatment of the primary disease, maintenance of enteral nutrition, and administration of hepatoprotective drugs such as adenosylmethionine. If low fibrinogen is found during physical examination, it is recommended to go to the hospital as soon as possible, and standardize the treatment under the guidance of the doctor to ensure a good prognosis of the disease.