The drugs for treating gastric ulcer should be determined according to the patient’s etiology and condition, mainly including gastric acid inhibition, protection of gastric mucosa, and anti-H. pylori. The etiology of gastric ulcer is mainly H. pylori infection and damage by NSAIDs. Inflammation of the mucosa occurs after H. pylori infection, and the ability to resist damage is weakened, and the role of physicochemical damage factors is relatively enhanced. Aspirin and NSAIDs can directly damage the mucosa and can inhibit mucosal regeneration and repair functions. In both cases, mucosal damage is not self-repairing. Minor damage can gradually worsen and become ulcers. For the pharmacological treatment of gastric ulcers, the presence of H. pylori infection and the history of aspirin and NSAID use should be evaluated first. If H. pylori infection is present, strive to eradicate the bacteria to the greatest extent possible. The current regimen for eradication of H. pylori is a quadruple therapy of 1 proton pump inhibitor (PPI) + 2 antibiotics + 1 bismuth agent for 14 days. Commonly used PPI (proton pump inhibitors) are rabeprazole, pantoprazole, etc., antibiotics are clarithromycin, amoxicillin, metronidazole furazolidone, quinolone, tetracycline, bismuth is bismuth potassium citrate, etc. If taking aspirin or NSAIDs, discontinue them as much as possible if other conditions allow. If discontinuation is not possible, eradicate H. pylori as much as possible because, in the presence of H. pylori infection, the development of mucosal damage and ulcers caused by aspirin or NSAIDs is significantly increased and is less likely to occur if there is no bacterial infection. Of course, in patients with multiple coexisting diseases or discontinuation of aspirin, etc. may not be realistic, and in such cases, continuous application of powerful gastric acid inhibiting agents such as lazoles is required, and mucosal protective agents can also be added together to maintain treatment for ulcer healing or to reduce the chance of serious complications such as bleeding and perforation. In general, the drugs for the treatment of gastric ulcer should be determined according to the cause and condition of the patient, and the patient must regulate the use of drugs under the guidance of the doctor in order to achieve the purpose of early recovery.