The oocyte grows surrounded by granulosa cells and protected by follicular fluid. The perfect maturation of an egg cell depends on the support and nutrition provided to it by the growing environment and largely determines the viability of the embryo. Because the embryo’s genes do not begin to activate until the cleavage stage, and new mitochondria are not generated until the blastocyst stage, the mitochondria carried by the egg cell, which serve as the embryo’s energy factory, play an important role in fertilization and embryonic development until the embryo is deposited in the womb. Unfavorable factors, including advanced age, obesity, smoking, alcoholism, oxidative stress, and psychological stress can adversely affect the egg cell. In contrast, proper androgen supplementation, proper diet, exercise, nutritional supplements and psychological interventions favor follicular growth. Below we introduce two complementary medications to improve ovarian function and responsiveness. Coenzyme Q10 Coenzyme Q10 is commonly found on the inner mitochondrial membrane and is both an important energy producing tool and a potent intracellular antioxidant. It has been shown that Coenzyme Q10 levels in the body gradually decline with age. Defects in the Coenzyme Q10 gene are associated with a range of disorders of the nervous system, skeletal muscular system and endocrine system. The ovary is a preferential and selective absorber of exogenous Coenzyme Q10, and a 2-month pre-treatment of Coenzyme Q10 in older women significantly improves ovarian response to ovulation stimulating drugs. Experiments with bovine embryos cultured in vitro showed that the use of coenzyme Q10 significantly accelerated the rate of division of the early embryo, increased the formation of zygotic embryos, and increased the expansion of the blastocyst cavity and the volume of the inner fine mass. These changes may stem from the fact that coenzyme Q10 increases the energy (ATP) output of intracellular mitochondria. Clinical trials have shown that the rate of aneuploidy was significantly lower in older women with ovulation after CoQ10 premedication than in controls (46.5% vs. 62.8%), but no statistically significant difference was found in the clinical pregnancy rate (33% vs. 26.7%). At the same time, improving egg quality is the key to minimizing the loss of haploid embryos. DHEA DHEA, or dehydroepiandrosterone, is an androgen that is converted to testosterone and estradiol in the body. Androgens in the follicle promote AMH secretion from the granulosa cells, inhibit follicular atresia and promote follicular growth and development by increasing FSH receptors. With age, the number of recruitable follicles in the ovarian memory decreases and the quality of follicular cells declines, leading to decreased fertility and sex hormone deficiency, with a gradual decrease in serum total testosterone, free testosterone, and DHEA concentrations. Therefore, in patients with reduced ovarian reserve or poor ovarian response, moderate and regular supplementation of DHEA may improve clinical pregnancy and live birth rates. Another study showed that the combination of DHEA and CoQ10 increased the basal follicle count and ovarian responsiveness in patients with diminished ovarian reserve compared with DHEA alone. With the development of society and the liberalization of the two-child policy, more and more women of advanced age are seeking the help of assisted reproductive technology. Meeting the fertility needs of women with diminished ovarian function is our goal and research direction. Of course, these health medicines are mainly for women with low ovarian function, so it is recommended that you consult a fertility doctor before taking them.