Sodium vitrate should not be injected when there is an infection or inflammation of the knee joint, impaired venous and lymphatic reflux in the leg, or an allergy to sodium vitrate. Sodium vitrate is the main component of synovial fluid, which acts as a lubricant in the joint cavity, and is used clinically for conditions such as osteoarthritis of the knee and frozen shoulder. When septic arthritis and septic synovitis are present, there is obvious swelling and fluid accumulation in the joints, and its use during the infectious period may aggravate the symptoms of infection, cause joint pain, and restriction of movement, etc., so sodium vitrate cannot be injected. When there is an obstacle to venous and lymphatic reflux in the leg, it is easy to affect the metabolism of the drug, which may cause an increase in the pressure of sodium vitreous acid accumulation in the cavity and cause pain, so sodium vitreous acid can also not be used. Individual patients may experience pain, rash, itching and other symptoms at the injection site, and the symptoms persist after a few days, which may be an allergic reaction, and the drug should be discontinued. In addition, during the use of sodium vitrate, it must be injected into the joint cavity, such as injected into other parts (soft tissue, synovium, ligaments) is prone to cause pain or localized swelling, sodium vitrate can not be in contact with drugs containing Jelqing in order to avoid turbidity. The use of drugs need to be under the guidance of a doctor.