High serum phosphocreatine kinase may be due to a transient increase in the body due to exercise or the use of certain medications, or it may be due to myocardial infarction or muscle damage. Serum phosphocreatine kinase is found in a wide range of muscle tissues such as skeletal muscle and cardiac muscle and is clinically important. A transient elevation of serum phosphocreatine kinase may occur during the test if more strenuous exercise is performed prior to the test. Taking a certain drug may also lead to high serum phosphocreatine kinase due to an adverse reaction to the drug, such as clofibrate capsules. Pathologic factors are more numerous, such as progressive muscular dystrophy, polymyositis, muscle injury, myocardial infarction, etc. can cause high serum phosphocreatine kinase. In order to clarify the diagnosis, it is necessary to go to the corresponding department of the hospital in time, complete the relevant examination, and cooperate with the doctor for active treatment.