Sleeping with low back pain requires general treatment, physiotherapy, medication or surgery, and there is no fastest way to relieve it. Sleeping with back pain may be related to lumbar disc herniation, ankylosing spondylitis, pyelonephritis, excessive exercise and so on. 1. Lumbar disc herniation: For lumbar disc herniation, you can take vitamin B12 and other nutritive nerve drugs, ibuprofen and other non-steroidal anti-inflammatory drugs as prescribed by your doctor. Physical therapy such as lumbar traction and ultrasound can also be performed under professional guidance. If the effect of conservative treatment is not obvious, decompression surgery can be considered. 2. Ankylosing spondylitis: For ankylosing spondylitis, oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib, immunosuppressants such as methotrexate and biologics such as etanercept can be prescribed. For severe damage to the hip joints, hip arthroplasty can be considered, and range of motion and stretching exercises can improve joint flexibility and muscle strength. 3. Pyelonephritis: For pyelonephritis, rest, drink more water and urinate more. Antibiotics such as levofloxacin can be taken orally as prescribed by the doctor. 4. Excessive exercise: For lactic acid buildup caused by excessive exercise, you can take proper rest, which can be relieved by yourself. There are other reasons for sleeping back pain, if rest continues not to relieve, it is recommended to go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, standardized treatment under the guidance of the doctor, do not blindly use their own medication, so as not to delay the condition.