Highly aggressive B-cell lymphoma is more difficult to cure and the prognosis is poor. The main treatment should be autologous stem cell transplantation after chemotherapy or allogeneic stem cell transplantation. Highly aggressive B-cell lymphoma mainly refers to aggressive lymphoma with C-myc, bcl-2, bcl-6 gene rearrangement, mainly refers to diffuse large B-cell lymphoma, Burkitt’s lymphoma and other pathological types, the remission rate of chemotherapy is relatively poor, after remission is also prone to relapse, need to do the whole management after clear diagnosis, mainly planning to do autologous stem cell transplantation or allogeneic stem cell transplantation. It is difficult to achieve long-term sustained remission with chemotherapy plus melphalan alone.