Carotid soft plaques can be treated with plaque-stabilizing drugs such as atorvastatin and anti-platelet aggregation drugs such as aspirin, depending on the physician’s instructions. Soft plaque in the carotid artery carries the risk of persistent stenosis, occlusion, and embolism caused by plaque dislodgement, and requires timely assessment and intervention according to the condition. Usually, plaque stabilizing drugs such as atorvastatin and resuvastatin, as well as anti-platelet aggregation drugs such as aspirin, are prescribed. Statin lipid-lowering drugs may cause adverse reactions such as muscle aches and pains, liver function abnormalities, etc. and are contraindicated in allergic individuals; aspirin may cause adverse reactions such as skin mucosa and gastrointestinal bleeding, and is contraindicated in allergic individuals, among many other conditions. If carotid artery soft plaque leads to severe stenosis, such as stenosis greater than 70%, can consider intervention, the specific treatment method should follow the physician’s instructions. Do not self-medicate if you have carotid artery soft plaque. It is recommended to go to the regular hospital in time, follow the doctor’s instructions to use medication, pay attention to observe whether there is any special discomfort after taking the medication, and regularly review the follow-up examination.