Differentiated cancers are cancers in which the tumor cells and tissues are morphologically and functionally similar to the normal cells and tissues from which they originate. The so-called differentiation, which represents the degree of maturity of tumor cells and the difference in differentiation from normal cells, can be divided into four types: highly differentiated, moderately differentiated, poorly differentiated and undifferentiated in general. 1. High differentiation, indicating that the tumor cells are close to normal cells, suggests that the malignancy of the tumor is relatively low, and also indicates that the sensitivity to radiotherapy treatment is relatively low. 2. Moderately differentiated: between highly differentiated and poorly differentiated. 3. low differentiation: indicating that the tumor cells are more different from normal cells, the malignant degree of the tumor is higher, it is easy to metastasize, and the sensitivity to radiotherapy is higher. 4. Undifferentiated, no obvious heterogeneity is seen between tumor cells and cells of origin, with the highest degree of malignancy and the worst prognosis. In conclusion, according to the degree of tumor differentiation, it helps to determine the degree of malignancy, and the degree of malignancy of differentiated cancers is relatively good. Diagnosed cancer should go to the hospital immediately, listen to the clinician’s advice and cooperate with the treatment.