The generic name of Ambidexin is bivalirudin, and the fever in the joints after taking it may be related to the presence of inflammation within the joints, infections, and lesions in the surrounding soft tissues. Bivalirudin is primarily a condition-improving drug for osteoarthritis. It can treat osteoarthritis by acting as an anti-inflammatory and pain reliever, promoting the synthesis of cartilage, and slowing down the progression of the disease. Common adverse reactions include nausea or vomiting, epigastric pain, and mild diarrhea. Occasionally, it may cause a yellowish coloration of the urine, but this is usually not clinically significant. It is contraindicated in patients with known hypersensitivity to the product or a history of hypersensitivity to anthraquinone derivatives, and is contraindicated in pregnant women, nursing mothers, and children under 15 years of age. Joint fever can be caused by the following factors: 1. Inflammation within the joints: e.g. osteoarthritis, the joints may show symptoms of redness, swelling, heat and pain. 2. Secondary infections: such as systemic septic infections, joint fever may also occur once secondary infections occur within the joints. 3. Soft tissue lesions around the joints: such as cellulitis or dengue around the joints may also appear joint fever. Therefore, bisacodyl does not cause joint fever, but rather can play an analgesic and anti-inflammatory role, joint fever can be caused by other reasons. Bivalirudin should be used under the supervision of a doctor, avoid self-medication.