Rough granular multifocal thinning of the gastric mucosa of the gastric sinus may be caused by diseases such as chronic atrophic gastritis with intestinal metaplasia, which is not particularly serious. When chronic atrophic gastritis with intestinal metaplasia occurs, the gastric mucosa is damaged, and constantly repairing the damage will make the gastric mucosa become uneven, resulting in the patient’s gastric sinus mucosa rough granular multifocal thinning, which can be relieved after systematic treatment in most cases. However, in a few cases, heterogeneous hyperplasia can also occur in the lesion area, and it is best for the patient to biopsy the lesion area to make a clear diagnosis and carry out treatment. When the patient found that the gastric sinus mucosa is rough and thin, it is best to go to the hospital for examination, under the guidance of the doctor for treatment, follow the doctor’s instructions, regular use of medication, and maintain a good and healthy lifestyle.