Antihypertensive drugs commonly used in the treatment of hypertension include diuretics, calcium channel blockers, beta-blockers, angiotensin II receptor antagonists, ACEIs and so on. Treatment of drugs should follow the principle of individualization, there is no so-called “best” drug, follow the doctor’s instructions to use appropriate and effective drugs is the best. 1. There are many kinds of antihypertensive drugs for the treatment of hypertension, the common ones are: (1) Diuretics such as hydrochlorothiazide, etc., through sodium diuresis, reduce volume load to achieve the effect of blood pressure. (2) Calcium channel blockers, such as amlodipine, play a role in lowering blood pressure by blocking calcium channels on vascular smooth muscle cells. (3) β-blockers such as metoprolol are generally used in patients with coronary heart disease and cardiovascular disease. (4) Angiotensin II receptor antagonists such as chlorosartan. (5) ACEI drugs, such as ramipril, fosinopril, and so on. 2. Since the indications, contraindications and adverse effects of different drugs are different, doctors will choose the most suitable drug for treatment according to the patient’s condition and therapeutic effect. Hypertensive patients should follow the doctor’s instructions for regular use of medication to avoid affecting the effect of medication, and should not adjust the dosage or change antihypertensive drugs without authorization to avoid serious consequences.