Decree lines are located at the combination line of nose, cheeks and upper lip. Decree lines at the corners of the mouth are generally not harmful to the body, and common removal methods include injectable fillers, surgery, radio frequency, and so on. 1. Injectable fillers: Injectable fillers include hyaluronic acid (hyaluronic acid) filler, poly(L-lactic acid) filler, collagen filler, and autologous fat particles injectable filler, etc. Hyaluronic acid is the main ingredient of extracellular matrix, which is easy to be degraded and absorbed, and needs to be injected repeatedly with a high degree of safety. 2. Surgical treatment: mainly through surgery to change some of the aging anatomy of the face, including zygomatic fat pad lifting, buried guide suture law, suction disarticulation nasolabial fold leveling and free SMAS flap filling surgery. 3. Radiofrequency treatment: high-frequency electromagnetic waves act on dermal collagen to promote collagen fibers and elastic fibers to contract and regenerate and reorganize, eliminating wrinkles. Generally, it is not harmful to the body and no special treatment is needed. If there is a need to remove the lines, it is recommended that patients undergo treatment in a regular professional medical institution.