Edema of the lower body is most commonly associated with iliac vein thrombosis and is also prone to lethal complications, inducing pulmonary embolism. Once the diagnosis is clear, interventional therapy can be performed with vena cava filter implantation, and aggressive anticoagulation is also warranted. Elevating the lower limbs bilaterally can also promote venous blood return, and can also significantly relieve the patient’s lower limb swelling and pain and discomfort. During the treatment period, attention should be paid to the prevention of infection, because severe venous blood return abnormality can easily lead to superficial soft tissue vasodilatation, as well as skin tension blisters, and also easy to secondary infection. If the edema is caused by anemia and hypoproteinemia, human albumin or plasma should be supplemented intravenously, and diuretics should be applied to relieve pain and discomfort, and compression stockings can be worn during activities.