Sulfapyridine suppository is one of the common drugs for the treatment of ulcerative colitis, which belongs to the sulfonamide class and is a broad-spectrum antibacterial drug with anti-inflammatory effect. Ulcerative colitis is a chronic non-specific inflammatory disease of the colon, involving mainly the mucosa and submucosa of the colon, with the left associated colon being the most common, with the main clinical manifestations being diarrhea, abdominal pain and mucopurulent stools. The goal of treatment in the active phase of ulcerative colitis is to control inflammation and relieve symptoms as soon as possible, and maintenance therapy should be continued during the remission phase to prevent recurrence.