The main causes of lymph node pain on pressure include: lymph node inflammation, lymph node tuberculosis and lymph node metastasis of malignant tumors and other diseases. 1. Lymphadenitis: caused by various infectious factors, usually accompanied by enlarged lymph nodes, localized redness and swelling, pain is obvious when pressed, and the symptoms of lymph node pain and enlargement disappear after anti-infectious treatment. 2. Lymph node tuberculosis: patients usually have a history of tuberculosis, lymph nodes are usually not red and swollen, anti-tuberculosis treatment is effective, the symptoms of lymph node pain and enlargement need a longer period of treatment to improve. 3. Lymph node metastasis of malignant tumor: usually the lymph nodes are hard, poor mobility, and the symptoms of lymph node pain and enlargement are not relieved after anti-infective treatment. Lymph node pressure pain is also seen in other causes, should be consulted as soon as possible, under the guidance of professional doctors to standardize the treatment, so as not to delay the condition.