The HPV vaccine is not necessary after the quadrivalent vaccine, because the HPV quadrivalent vaccine mainly prevents HPV6, HPV11, HPV16 and HPV18 infections in clinical practice, while the nine-valent vaccine prevents five additional high-risk HPV infections on top of the quadrivalent vaccine, so it is not necessary to receive the nine-valent vaccine after the quadrivalent vaccine. After receiving the quadrivalent vaccine, it is recommended that clinical attention should be paid to avoid pregnancy for six months and that cervical cancer screening should be done before preparing for pregnancy. The vaccine does not mean that 100% of patients will not get cervical cancer again after the vaccine, but the preventive effect is about 90% or more, and about 10% of patients will still get cervical cancer after the vaccine, so it is still necessary to be checked.