Swelling of the penile foreskin is commonly seen in the clinic, such as circumcision, foreskin inlay, foreskin trauma or surgery, etc. Different diseases require the use of different drugs to reduce swelling, such as amoxicillin and other antibacterial drugs, ketoconazole cream and other antifungal drugs. 1. circumcision: if the bacterial infection, you can take oral amoxicillin and other antibacterial drugs, but also local topical erythromycin ointment and other antibacterial drugs, if the fungal infection is caused by the local topical ketoconazole ointment, terbinafine ointment, and other antifungal drugs treatment. 2. Foreskin inlay: mostly seen in patients with prepuce, because of the narrow opening of the foreskin, after turning down the inlay will occur, impede the blood and lymphatic reflux, and then there is a bruise and swelling of the foreskin, blood timely manipulation of the reset or surgical treatment, and after that, the swelling can be gradually reduced, and if necessary, you can use potassium permanganate solution for cleaning and soaking. 3. Foreskin trauma or surgery: such as foreskin contusion, circumcision, etc., in addition to the use of potassium permanganate solution soak, you can also use magnesium sulfate for hot and wet compress treatment. The above medications should be used under the guidance of a doctor. Swelling of the penile foreskin may also be caused by other factors, which require different treatments. Patients are advised to go to regular hospitals for timely consultation and treatment for early recovery.