Sour saliva, difficult to stomach may be reflux esophagitis, chronic gastritis and other diseases caused by the need for targeted treatment under the guidance of a doctor, drug therapy, including omeprazole, thioglycollate and so on. 1. Reflux esophagitis: there can be reflux symptoms, reflux to the oral cavity will appear sour saliva, stomach; sleep can raise the head of the bed, avoid eating chocolate, strong tea and other lower esophageal sphincter food, can be used in accordance with the doctor’s instructions, such as omeprazole, pantoprazole and other acid-suppressing drugs, moxapride and other gastric motivation drug therapy. 2. Chronic gastritis: abnormal peristalsis of gastrointestinal function, resulting in gastric juice can reflux to the oral cavity and then appear saliva acidic situation, can also be accompanied by abdominal discomfort; can be prescribed the use of Pantoprazole and other acid-suppressing drugs, doxorubicin to promote gastrointestinal dynamics treatment, aluminum thioglycollate and other gastric mucous membrane protection agent treatment. Sour saliva, stomach discomfort is recommended to go to the hospital, under the guidance of the doctor’s medication.