The location of right shoulder pain of liver cancer usually cannot be described precisely, which can be the front shoulder or the back shoulder. Hepatocellular carcinoma is a common malignant tumor of digestive system caused by bacteria, virus, heredity and other reasons, and due to anatomical factors, patients may have the symptom of right shoulder pain. One of its characteristics is that the location of pain cannot be accurately described, and the pain is mostly hidden and does not affect the patient’s life. Right shoulder pain of hepatocellular carcinoma often needs to be differentiated from frozen shoulder, which can be manifested as limitation of shoulder joint movement, and in serious cases, it is impossible to comb hair and touch back with backhand. Most of the patients can point out the exact pain point, and the pain is more intense, which can involve the middle part of upper arm. And liver cancer patients may also combine with symptoms such as fatigue, fever, hidden pain in right upper abdomen and loss of appetite. Patients should consult the doctor in time, complete relevant examination, clarify the cause of shoulder pain, and then adopt corresponding treatment plan.