A bilirubin of 40 μmol/l is considered high and does not usually require treatment if it is due to physiological factors such as late nights and alcoholism. If it is caused by viral hepatitis, hemolytic anemia and other pathological factors, you need to actively receive treatment. 1. Physiological factors: If there are recent bad habits such as staying up late, overwork, alcoholism, etc., it may cause bilirubin elevation up to 40 μmol/l, which can be gradually relieved after improving the habits, and treatment is not necessary. The liver function of newborns is not well developed, and physiological jaundice of newborns may appear 2~3 days after birth, which usually does not need to be treated, and can subside by itself. 2. Pathological factors: elevated bilirubin may also be caused by disease factors, which need to be actively treated. If it is caused by hemolytic anemia and other hemolytic diseases, it can be treated by taking glucocorticoid drugs, plasma replacement, bone marrow transplantation and other methods. If the disease is caused by viral hepatitis, fatty liver, cirrhosis and other liver cell damage, it can be treated by taking antiviral drugs such as entecavir for antiviral treatment, and by taking drugs to protect liver cells such as silymarin and reduced glutathione. If it is due to biliary obstructive diseases such as gallbladder stones or bile duct stones, it can be treated by taking choleretic drugs such as ursodeoxycholic acid, or by surgery. If the patient has 40 μmol/l for a long time, it is recommended to consult a doctor to identify the cause of the disease and carry out targeted treatment. The medication should be taken strictly according to the doctor’s prescription.