Moderate risk of folate metabolism requires doubling the continuous intake of folic acid to at least 0.8 mg per day of supplementation, and care should be taken to follow medical advice for dosage. Oral folic acid can be taken daily for 3 to 6 months before pregnancy until the third month of pregnancy. Oral folic acid can prevent fetal neural tube malformation, congenital heart disease, cleft lip and palate, Down syndrome, growth retardation and low birth weight. It also reduces the risk of placental abruption, spontaneous abortion, preterm labor, preeclampsia, and postpartum depression in pregnant women. Pregnant women with moderate risk of folate metabolism have a relatively low rate of folate absorption and need more folate than the usual pregnant women. It is usually necessary to double the continuous intake of folic acid to at least 0.8mg per day, and care should be taken to follow the doctor’s instructions for dosage. In addition, for moderate risk of folate metabolism, there is no need to be overly nervous, this is only a metabolic state, does not mean that the disease occurs, and timely doubling of folic acid supplementation according to the doctor’s instructions can be.