“Chronic granulocytic leukemia is a malignant clonal proliferative disease originating from pluripotent hematopoietic stem cells. 1. The pathological changes of chronic granulomatous leukemia are the excessive proliferation of myeloid cells, which can be seen in the peripheral blood neutrophil increase, naïve granulocytes, basophilic granulocytes, thrombocytosis, and the clinical manifestations are anemia, fever and splenomegaly. Diagnosis is mainly based on routine blood tests and cytogenetic tests. 2. The treatment of lentigo is chronic phase drug (tyrosine kinase inhibitor, interferon-alpha, hydroxyurea, anagrelide) therapy, hematopoietic stem cell transplantation, leukocyte monoclonal collection, radiation therapy, splenectomy; accelerated and acute phase chemotherapy. When there are manifestations such as anemia, fever and splenomegaly, it is necessary to consult the doctor at the first time for early diagnosis and treatment. The above drugs need to be used under doctor’s supervision.