Irbesartan usually works half an hour after taking the drug, and the effect peaks 4-6 hours after taking the drug, and the effect is maintained for 24 hours. Smooth blood pressure lowering, blood pressure fluctuation is small. Irbesartan is an angiotensin II antagonist blood pressure-lowering drug, belonging to the sartan class of antihypertensive a kind of, is clinically recommended for hypertension with proteinuria. Irbesartan is usually taken once a day, one tablet at a time, half an hour after taking the drug to play a role in 4-6 hours after taking the drug to reach the peak effect, the effect of the drug to maintain 24 hours. It is a stable antihypertensive drug with little fluctuation in blood pressure. Peak plasma concentration can be reached in about 1.5-2 hours after oral administration. Total body clearance and renal clearance are 157～176 ml/min and 3.0～3.5 ml/min respectively, and the terminal clearance half-life of Irbesartan is 11～15 h. The total body clearance and renal clearance are 157～176 ml/min and 3.0～3.5 ml/min respectively. While taking Irbesartan, pay attention to the adverse reactions of the drug, common adverse reactions include dizziness, cold sweat, tachycardia, edema and so on. Irbesartan should be used with caution in hepatic and renal insufficiency, and is contraindicated in pregnant women, lactating women, hyperkalemia, and patients with renal artery vascular malformation. During the period of taking the drug, pay attention to monitoring the change of blood pressure, if any discomfort promptly consult a doctor.