Scalp pain during a cold is caused by the following factors: 1. Common colds are caused by bacteria, viruses, fungi, pathogens, microorganisms, etc. Pathogenic microorganisms produce a strong pyrogen in the body, which has a certain effect on the thermoregulatory center. It also releases inflammatory factors such as prostaglandins, prostacyclin and bradykinin. This substance has a painful effect on the body and therefore causes scalp pain. 2. Inflammatory factors such as interleukin-2, interleukin-4 and interleukin-6 are released under the action of inflammatory mediators, and inflammatory factors enhance the body’s pain threshold sensitivity to pain. 3. Histamine is provoked to release bradykinin, a pain-causing factor. This pain-causing substance can cause pain in the scalp and peripheral joints.4. If the body is deprived of oxygen due to fever during a cold or fever, the breakdown of lactic acid in the body will increase, and the accumulation of lactic acid in the body will also lead to scalp pain.