Spots on both sides of the cheeks are mostly seen in women, and most of them are seen in women who have given birth. The most common causes are freckles or chloasma, frequent sun exposure and lack of attention to sun protection can aggravate skin damage, which can easily lead to freckles on both sides of the cheeks, and lack of sleep or changes in estrogen and progesterone levels can lead to freckles on both sides of the cheeks. Systemic lupus erythematosus as well as diseases of the endocrine system can also lead to spots on both sides of the cheeks. Patients should pay attention to sun protection, apply sunscreen and use umbrellas when going out. Under hot and strong light condition, the facial skin is easy to develop spots, patients can drink more water, eat more food containing vitamin C and vitamin E, and eat less greasy and spicy food to reduce the chance of developing spots on both sides of the cheeks.