The presence of four plus signs in urine protein suggests the presence of proteinuria, which is mostly caused by kidney damage and requires further examination. It is recommended to be hospitalized for twenty-four hour urine protein quantitative examination, as well as renal function, renal blood flow examination, renal ultrasound, if necessary, need to carry out renal biopsy examination. It is common in kidney disease due to various causes, which leads to the destruction of glomerular filtration membrane. Protein in the blood leaks out of the body through the damaged filtration membrane and enters the urine as proteinuria. Long-term this leads to the patient hypoproteinemia and malnutrition, or edema and other changes. And patients may also be accompanied by renal function impairment, need to further measure plasma urea nitrogen, creatinine and other related treatment, in order to avoid irreversible damage to the kidneys.