Herpes mouth is clinically most commonly seen as herpes simplex, a viral disease mainly caused by herpes simplex virus type I. Red papules and clusters of blisters can be seen on the lips, and they can be accompanied by a tingling sensation. For treatment, oral ganciclovir dispersible tablets and mecobalamin tablets can be taken, and for topical application, a mixture of erythromycin eye ointment and mometasone furoate cream can be used. After the above treatment, the patient’s herpes can be quickly relieved and cured. If blisters with fluid exudation appear during the treatment process, you can also apply local cold compresses with compound cypress lotion, mix with topical comfrey oil and epidermal growth factor gel, and take oral rosmarinic acid capsules during the treatment period. Therefore, for herpes on the lips, patients need to go to a regular hospital and be treated under the guidance of a dermatologist. During the treatment period, it is necessary to abstain from spicy and irritating food, alcohol, and avoid eating food that is too hot as well as boiling water.