Rivaroxaban belongs to a new type of oral anticoagulant, Polivir is a trade name, its main ingredient is clopidogrel, belongs to the antiplatelet drugs, the above two drugs belong to different kinds of drugs, so for different diseases have their own advantages, can’t directly compare which one is better. Rivaroxaban is mainly used in venous thrombosis or pulmonary embolism and other diseases, can also be used in atrial fibrillation to prevent the formation of blood clots. Clopidogrel is mainly used to prevent angina attacks and acute myocardial infarction, or to prevent cerebral infarction and other related diseases. Therefore, for different diseases, rivaroxaban and clopidogrel have their own advantages. For diseases related to pulmonary embolism or atrial fibrillation, rivaroxaban is more effective than clopidogrel. However, if it is used to prevent angina attacks or heart attacks, or to prevent related diseases such as cerebral infarction, clopidogrel is better than rivaroxaban. Rivaroxaban can lead to adverse reactions such as bleeding, and may even cause complications such as gastrointestinal hemorrhage and intracranial hemorrhage, which may be life-threatening; it should be contraindicated for those with active bleeding, as well as for women during pregnancy. Clopidogrel may cause thrombocytopenia as well as adverse reactions such as bleeding, active bleeding, severe liver function abnormalities, as well as those who are allergic to the product are contraindicated. Therefore, rivaroxaban and clopidogrel should be used rationally under the guidance of a doctor in conjunction with specific conditions.