The painfulness of chemotherapy for gastric cancer is mainly related to the protocol of gastric cancer and individual’s physical constitution. After radical surgery for progressive gastric cancer, regardless of whether there is lymph node metastasis, chemotherapy is required. The main side effects of chemotherapy are as follows: 1. chemotherapy drugs may cause gastrointestinal symptoms, such as nausea, vomiting and poor appetite, and some patients have unbearable symptoms. 2. chemotherapy drugs may damage liver and kidney functions, so liver and kidney functions need to be reviewed during chemotherapy. 3. chemotherapy drugs often inhibit bone marrow and cause trilineage reduction, and severe white blood cell reduction may cause infection. 4. Chemotherapy drugs may cause hair loss, mental depression, peripheral neuropathy such as numbness and pain sensation in patients.